Morphological alterations and time-kill studies of the essential oil from the leaves of Coriandrum sativum L. on Candida albicans

Abstract

The objective of this study was to evaluate the morphological alterations and time-kill of the essential oil of the leaves of C. sativum L. on strains of C. albicans. The essential oil was submitted to gas chromatography-mass spectrometry analysis. The predominant component identified was linalool (39.78%). Minimal inhibitory concentration and minimal fungicidal concentration of the essential oil were respectively 512 and 1024 μg.mL-1 for 90% of the strains tested. In the time-kill curves, the essential oil showed a concentration-dependent fungicidal effect. In the micromorphology assay it caused a significant reduction in pseudohyphae, an important pathogenic factor of C. albicans.