Pretreatment with kuanxiong aerosol protects against coronary microvascular dysfunction

Abstract

This study investigates the efficacy and mechanisms of Kuanxiong Aerosol (KXA) on coronary microvascular dysfunction (CMD) in rats. Thirty-two Sprague-Dawley rats were divided into control, model, KXA, and nicorandil groups, receiving respective treatments for three weeks. The CMD model was established by injecting lauric acid into the left ventricle. Compared to the model group, the KXA group showed significant reductions in serum CK-MB, LDH, cTnI, ET-1, TNF-α, IL-6, MDA, and ROS (p<0.01) and increased NO and SOD levels (p<0.01). KXA mitigated apoptosis and ameliorated CMD-associated pathological alterations. Pretreatment with KXA improves endothelial function and microvascular structure by counteracting inflammation, oxidative stress, and apoptosis, thereby improving CMD.