Alleviative effect of dihydroquercetin on chronic heart failure in rats and its impact on inflammatory response, oxidative stress and cardiac myocyte apoptosis

Abstract

To investigate the alleviative effect of dihydroquercetin on chronic heart failure (CHF) in rats and the mechanisms. Thirty rats were randomly divided into sham, model and treatment groups. The CHF model was established in model and treatment groups. The treatment group was treated with 50 μg/kg dihydroquercetin for four weeks. After treatment, compared with model group, in treatment group the cardiac structure and function indexes were improved, the serum creatine kinase, lactate dehydrogenase, cardiac troponin I, tumor necrosis factor α, interleukin 6 and malondialdehyde levels decreased, the serum superoxide dismutase level increased, the myocardial B-cell lymphoma 2, nuclear factor-erythroid 2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1) protein levels increased, and the myocardial Bax protein level decreased (all p<0.05). In conclusion, dihydroquercetin may alleviate CHF in rats by resisting inflammatory response and oxidative stress, reducing cardiac myocyte apoptosis and activating Nrf2/HO-1 signaling pathway.