Pedalitin from Isodon japonica, an inactivation of soybean lipoxygenase-1

Authors

  • Tae Joung Ha
  • Takahiko Isobe
  • Enrique Werner
  • Julio Alarcon
  • Isao Kubo
  • Carlos L. Cespedes

Keywords:

Rabdosia japonica, Pedalitin, Lipoxygenases inhibitor

Abstract

Pedalitin, isolated from the aerial part of Rabdosia japonica (Labiatae), inhibited soybean lipoxygenase-1 (EC 1.13.11.12, Type I) with an IC50 of 152.5 M. The progress curves for an enzyme reaction, pedalitin inactivate the lipoxygenase-1 in a time dependent, irreversible manner, exhibiting kinetics with a kinact/KI of 59.6 ± 10 mM-1min-1. In the pseudoperoxidase activity, pedalitin is very slowly oxidized by the soybean lipoxygenase-1 catalyzed decomposition of lipid hydroperoxides.

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Published

2016-01-31

How to Cite

Ha, T. J., Isobe, T., Werner, E., Alarcon, J., Kubo, I., & Cespedes, C. L. (2016). Pedalitin from Isodon japonica, an inactivation of soybean lipoxygenase-1. Boletín Latinoamericano Y Del Caribe De Plantas Medicinales Y Aromáticas, 15(1), 29-40. Retrieved from https://blacpma.ms-editions.cl/index.php/blacpma/article/view/254

Issue

Vol. 15 No. 1: January 2016

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.