Therapeutic effect of cirsimaritin on heart failure in rats and the underlying mechanisms

Abstract

To explore the effect on cirsimaritin on heart failure in rats and the mechanisms. The heart failure model with coronary artery ligation was established in 40 rats, which were then randomly divided into model and low-, middle- and high-dose cirsimaritin groups, 10 rats in each group. The 10 rats without coronary artery ligation were set as sham-operated group. The low-, middle- and high-dose cirsimaritin groups were treated with 20, 40 and 80 μg/kg cirsimaritin for one month, respectively. After treatment, compared with model group, in middle-dose cirsimaritin group the cardiac function indexes, heart and left ventricular indexes, myocardial injury indicators, and oxidative stress and inflammatory response indexes were significantly improved (all p<0.05). In conclusion, cirsimaritin has obvious therapeutic effect on heart failure in rats. It can effectively improve the cardiac function of rats, alleviate the myocardial injury, reduce the oxidative stress and decrease the inflammatory response.