Complete essential oils of Laurus nobilis inducing antinociceptive action by opioid mechanism in C-Reflex and spinal Wind-Up model in rat

This article is written in tribute to Dr. Claudio Laurido (RIP) died on October 2017, on the Third Anniversary of his Death

Authors

  • Carlos Valdés
  • Claudio Laurido
  • Bernardo Morales
  • Luisauris Jaimes
  • Raúl Vinet
  • José L. Martínez

DOI:

https://doi.org/10.37360/blacpma.20.19.4.29

Keywords:

Laurus nobilis L., Pain, C reflex, Spinal Wind-up

Abstract

The essential oil of Laurus nobilis L. was used to test their antinociceptive efficacy. It was applied intraperitoneally (i.p.) to rats subjected to a nociception test (C reflex and spinal wind-up). The results showed that the essential oil applied at higher doses (0.06 mg/Kg) causes a complete abolition of the spinal wind-up, while the C reflex was unchanged, indicating a clear antinociceptive effect. At lower concentrations (0.012 mg/Kg), there was a lowering in the wind-up by 85% within ten minutes of the essential i.p. oil application. Interestingly, there was an effect of naloxone (0.08 mg/Kg i.p.) When applied, a change occurs that almost entirely reversed the antinociception caused by the essential oil from Laurus nobilis. We conclude that there is a significant antinociceptive effect of the essential oil of Laurus nobilis subjected to electric nociception. In addition, it was observed that naloxone reversed the antinociceptive effect (windup) produced by Laurus nobilis.

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Published

2020-07-28

How to Cite

Valdés, C., Laurido, C., Morales, B., Jaimes, L., Vinet, R., & Martínez, J. L. (2020). Complete essential oils of Laurus nobilis inducing antinociceptive action by opioid mechanism in C-Reflex and spinal Wind-Up model in rat: This article is written in tribute to Dr. Claudio Laurido (RIP) died on October 2017, on the Third Anniversary of his Death. Boletín Latinoamericano Y Del Caribe De Plantas Medicinales Y Aromáticas, 19(4), 420-427. https://doi.org/10.37360/blacpma.20.19.4.29

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